Drugs for the treatment of Parkinson's Disease

Introduction

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder that affects motor function. This disease has become an epidemic, affecting approximately 1 percent of individuals over the age of 65 years old [1]. It is caused by decreased dopamine production in the basal ganglia due to degeneration of dopamine-secreting neurons [2],[3]. Initially, PD sufferers may be asymptomatic with the first clinical symptoms appearing after 60% of the dopaminergic neurons have degenerated in the substantia nigra [4]. Cardinal symptoms of Parkinson disease include bradykinesia, akinesia, rigidity, and resting tremors [2],[5]. The exact cause of PD is unknown; however, contributing factors to may include trauma, infection, cortical degeneration, antipsychotic drugs and cerebrovascular disease [6][7][8][9]. If PD goes untreated, total incapacitation will occur due to uncontrolled motor problems. This is why it is extremely important for PD patients to be prescribed the proper drug regimen.

Epidemiology of Parkinson's Disease

Levodopa in the treatment of Parkinson's Disease

Anticholinergic Drugs in the treatment of Parkinson's Disease

MAO-B inhibitors in the treatment of Parkinson's Disease

Dopamine Agonist Drugs in the treatment of Parkinson's Disease

Physical Therapy Implications for Parkinson's Disease Drugs

Conclusion

References

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