Maturation (Remodeling) phase

The tissue is realigning along the lines of stress. Think cooked pasta which is disorganized and filled with fatty infiltrate is reforming into uncooked pasta, which is increased density of primary collagen and realigned parallel to the lines of force.

During the maturation phase of wound healing, unnecessary vessels formed in granulation tissue are removed by apoptosis, and type III collagen is largely replaced by type I. Collagen which was originally disorganized is cross-linked and aligned along tension lines. This phase can last a year or longer. Ultimately a scar made of collagen, containing a small number of fibroblasts is left.[1]


References

  1. http://en.wikipedia.org/wiki/Healing#Inflammation_phase