RA (Rheumatoid Arthritis)

Definition/Description

Rheumatoid arthritis (RA) is an autoimmune disease and a form of inflammatory arthritis that affects five or more joints. Autoimmune conditions occur when the body fights its own immune system. Instead of the immune system protecting the body, it attacks itself. In RA, the immune system attacks the lining of the joints, called the synovium. RA is a long-term disease that leads to inflammation of the joints and surrounding tissues and can also affect other organs. These tissues include tendon sheaths, bursa, and tendons. Symptoms may present as inflammation of joints, pain and fatigue, morning stiffness, and hot and warm joints that may be red. Furthermore, if not treated, RA can possibly lead to joint deformities in the later stages of the disease which then function of the joints could be lost permanently.

The disease course typically follows three possible paths:
a. Monocyclic: Having one episode that does not reoccur. This usually ends within 2-5 years of initial diagnosis.
b. Polycyclic: The disease severity varies over the course of the progression of the condition.
c. Progressive: Condition continues to become more severe and non-remitting.

[1][2]

Prevalence

The prevalence of Rheumatoid Arthritis is estimated between 1.5- 2.1 million US adults or 10 cases per every 1000 people. There are nearly three times as many women then men with the disease. RA is found all around the world, but does tend to be more prevalent in the Native American and white population.

The risk of RA increases with age. RA most commonly begins in women between the ages of 30 and 60. It often occurs later in life for men, but can happen at any age. When RA affects the pediatric population, it is called Juvenile Idiopathic Arthritis (JIA) and usually begins before the age of 16.
[2][3]

Characteristics/Clinical Presentation

Signs and Symptoms of RA:

  • Joint Pain: warmth, redness, tenderness, swelling
  • Joint Stiffness: increased in the mornings
  • Fatigue throughout the body
  • Fever
  • Weight Loss
  • Rheumatoid Nodules: small lumps of tissue felt under the skin
  • Symmetrical Patterns of affected joints
  • Most common joints: wrist, hand, fingers, cervical spine, shoulder, elbow, knee, hip, foot, and ankle
  • Prolong symptoms
  • Anemia
  • Neck Pain
  • Dry Eyes
  • Dry Mouth

[1][4]

<u>American Collage of Rheumatology Revised Criteria for Classification of Functional Status in Rheumatoid Arthritis
Class 1 Completely able to perform usual activities of daily living (Self care, vocational and avocational)
Class 2 Able to perform usual self care and vocational activates by limited in avocational
Class 3  Able to perform usual self care activities but limited in vocational and avocational activities
Class 4  Limited ability to perform usual self care, vocational, and avocational activities

[5]

Associated Co-morbidities

RA has many effects on individuals including mortality, hospitalization, work disability, increase in medical cost/expenses, decreases of quality of life, and chronic pain. On average, the chronic RA patient has two or more comorbid conditions.[6] This is significant because of the comorbidities effects on quality of life, functional status, prognosis and outcome.

Associated Co-morbidities:
a) Myocardial Infarction and Cardiovascular disease
b) Stroke
c) Peripheral Vascular Disease
d) Cancer (All)
e) Infection
f) Osteoporosis
g) GI disease
h) Psoriasis and other skin conditions
i) Cataract
[7]
Complications of RA:
Rheumatoid arthritis can affect nearly every part of the body. Even though the joints are most commonly affected, RA can also have effects on organs.
a) Damage to the lung tissue (rheumatoid lung)
b) Increased risk of hardening of the arteries
c) Spinal injury when the neck bones become damaged
d) Inflammation of the blood vessels (rheumatoid vasculitis), which can lead to skin, nerve, heart, and brain problems
e) Swelling and inflammation of the outer lining of the heart (pericarditis) and of the heart muscle (myocarditis), which can lead to congestive heart failure
f) Side effects from treatment and medication.
g) General deconditioning
h) Rheumatoid nodules
i) Vascular complications
j) Neurological complications
k) Cardiopulmonary complications
l) Ocular complications

[1][5][8]

Medications

Common Medications for RA
Medication Uses/ Effects Side Effects
NSAIDs Pain reliever Stomach irritation
Kidney function.
Gastrointestinal problems
Acetaminophen Pain reliever If taken in excessive, liver damage may occur which could potentially lead to liver failure
Aspirin Buffered Plain Decrease pain, swelling, inflammation Upset stomach
Tendency to bruise easily
Corticosteriods Decrease inflammation, swelling, redness, itching, and allergic reactions
Increased appetite
Indigestion,
Nervousness
Restlessness
Methylprednisolone
Prednisone
Used for severe flare ups Mood changes
Easy bruising
Increase risks of infections
Disease-modifying antirheumatic drugs (DMARDs) Relieve painful, swollen joints and slow joint damage May increase the risk of infection, hair loss, and kidney or liver damage
Azathioprine Used for patients who have not responded to other medications Cough or hoarseness
Fatigue
Abdominal issues
Cyclosporine Used for patients who have not responded to other Medications Increase Blood Pressure
Kidney Problems
Shaking/Trembling of hands
Leflunomide Reduces signs and symptoms
Slows down the process of degeneration of the joints.
Abdominal pain, nausea, vomiting, loss of appetite,
Sneezing
Sore Throat
Methotrexate Inhibits the metabolism of folic acid Low white blood cell counts, abdominal pain, fever, infection
Sulfasalazine Immunosuppressant  Abdominal pain, diarrhea, loss of appetite, nausea/vomiting
Headache, sensitivity to light
Aching joints
Biologic response modifiers Block the autoimmune response that is involved in the roll with inflammation Increase risk of infection
Tumor necrosis factor inhibitors Blocks the autoimmune response that is involved in the roll with prolong inflammation as seen in RA lymphoma, infections, congestive heart failure, and systemic side effects
Interleukin-1 inhibitor Decreases inflammation in moderate-severe RA

Abdominal Pain, Nausea, Vomiting, Headache

Selective costimulation modulator Anti-inflammatory Headache, dizziness, abdominal pain, dyspepsia, nausea, rash, flushing, urticaria, pruritus, and wheezing
CD20 antibody Depletes B Cells that are associated with autoimmune response Abdominal pain

[1][4]

Diagnostic Tests/Lab Tests/Lab Values

Diagnostic Criteria

Four out of the Following Seven Must be Present 

  • Morning Stiffness for an hour or greater
  • Arthritis of 3 or more of the following joints: right or left PIP, MCP, Wrist, Elbow, Knee, Ankle, and MTP Joint.
  • Arthritis of wrist, MCP, PIP
  • Symmetric involvement of a Joint
  • Rheumatoid nodules over bony prominences or extensor surfaces or in juxaarticular regions
  • Positive serum rheumatoid factor
  • Radiographic changes including erosion or bony decalcifications localized in or adjacent to joints.

[5]

<u>Diagnostic Tests
Test Description Purpose
C-reactive protein (CRP)
(Lab Test)
Blood Test Indicates inflammation. As the level of inflammation rises, so does the level of CRP. High levels of CRP over a long period of time may indicate more severe joint damage.
Erythrocyte sedimentation rate, also referred to as ESR or "sed rate"
(Lab Test)
Blood Test People with severe RA will generally have a higher ESR than one with less severe RA
Rheumatoid factor (RF)
Lab Test
Blood Test Indicates the presence of RA. When the immune system attacks itself, the body produces RF. 75% of people with RA are RF positive.
Cyclic citrullinated peptide (CCP)
Lab Test
Blood Test This test is usually given to people who are experiencing new symptoms of RA, in order to rule out other autoimmune diseases.
Bone Scans Imaging Detects inflammation
X-Ray Imaging Detects swelling of soft tissues and loss of bone density
Magnetic Resonance Imaging (MRI) Imaging Detects inflammation
Ultrasound Imaging Detects inflammation
  • There is no test that can determine for sure whether someone has RA. Most patients with RA will have some abnormal test results, although for some patients, all tests will be normal.

[4][9]

Etiology/Causes

Etiology

The cause of Rheumatoid Arthritis is unknown. RA occurs when the immune system attacks the synovium — the lining of the membranes that surround the joints. The resulting inflammation thickens the synovium, and can eventually invade and destroy the cartilage and bone within the joint. The tendons and ligaments that hold the joint together weaken and stretch, overtime. Gradually, the joint loses its shape and alignment.[2][10]

Classification of Progression of Rheumatoid Arthritis
Stage Description
I: Early 1. Early destructive changes on radiographic examination
2. Radiographic evidence of osteoporosis may be present
II: Moderate  1. Radiographic evidence of osteoporosis, with or without slight subchondral bone destruction; slight cartilage destruction may be present
2.No joint deformities, although limitation of joint mobility may be present
3. Adjacent muscle atrophy
4. Extra-articular soft tissue lesions, such as nodules and tenosynovitis may be present
III. Severe 1. Radiographic evidence of cartilage and bone destruction, in addition to osteoporosis
2. Joint deformity, such as subluxation, ulnar deviation, or hyperextension, without fibrous or bony ankylosis
3. Extensive muscle atrophy
4. Extra-articular soft tissue lesions, such as nodules and tenosynovitis may be present
IV. Terminal 1. Fibrous or bony ankylosis
2. Criteria of Stage III

[5]

Risk Factors:

Although there is no known cause for RA, it is believed that certain factors can increase an individual’s risk for developing RA due to the interaction between genetic factors and environmental exposures:
a) Smoking: A history of smoking is associated with a modest to moderate increased risk of RA onset.
b) Gender: The incidence of RA is two to three times higher in women than men.

c) Age: Rheumatoid arthritis can occur at any age, but it most commonly begins between the ages of 40 and 60.
d) Family History: Family history can indicate a higher risk for RA.
e) Reproductive and breastfeeding history
          a. Live birth history: Women who have never had a live birth have a slight to moderately increased risk of  RA.
          b. Breastfeeding: Recent population based studies have found that RA is less common among women who breastfeed.
          c. Menstrual history: Women with irregular menses or a shortened menstrual history have an increased risk of RA.
          d. Oral contraceptives (OC): Women who had ever used OCs had a modest to moderate decrease in risk of RA.
[4]

Prognosis

The prognosis of RA depends on the severity of symptoms and early intervention. People with rheumatoid factor, the anti-CCP antibody, or subcutaneous nodules have a more severe form of the disease. People who develop RA at younger ages also tend to progress quicker.[8]

  • 50% Disabled at work within 10 years
  • 66% Significant trouble with ADL’s after 15 years
  • Patients with severe RA may die 10-15 years earlier
    [1]

Systemic Involvement

Malignant Hypertonic Osteoarthropathy, lymphoma, Leukemia, Carcinoma Polyarthritis 
Hematologic Sickle cell anemia, Thalassemia, Multiple Myeloma, Amyloidosis
Gastrointestinal Whipple disease, primary biliary cirrhosis, Spondyloarthropathies, hemochromatosis
Endocrinopathies DM, hypothyroidism, hyperthyroidism, hyperparathyroidism, acromegaly
Extra-articular Manifestations  Many of the extra-articular manifestations of RA are associated with increased disease activity and with markers of inflammation, such as high levels of rheumatoid factor (RF) and C-reactive protein (CRP).

[11]

Medical Management (current best evidence)

The goal of medical management for RA is to prevent or control joint damage, prevent loss of function, and decrease pain.

Medications: See full list in <a href="http://www.physio-pedia.com/RA_(Rheumatoid_Arthritis)#Medications">medication section</a>

  • Disease-modifying antirheumatic drugs (DMARDs)- Slow the progression of rheumatoid arthritis and save the joints and other tissues from permanent damage.
  • Immunosuppressants- Control the immune system
  • TNF-alpha inhibitors- Inhibit the inflammatory substance produced by the body and help reduce pain, morning stiffness, and tender or swollen joints.
  • Other drugs- Target a variety of processes involved with inflammation in your body

  [3]

Surgical Treatment: If medications fail to prevent joint damage, surgical intervention may be needed to repair the joints, restore ability, decrease pain, and correct deformities.

  • Total Joint Replacement
  • Tendon Repair
  • Joint Fusion

[4]

SupplementsResearch suggests that there are vitamins and minerals which may have an effect on RA. These effects range from reducing joint inflammation to improving bone health. Some of the vitamins and minerals are listed below. It is recommended to consult your primary care physician before consuming any of the supplements listed below.

  • Calcium
  • Copper
  • Fluoride
  • Iron
  • Magnesium
  • Selenium
  • Vitamin A
  • Vitamin B-1
  • Vitamin B-12
  • Vitamin B-3
  • Vitamin B-6
  • Vitamin D
  • Vitamin K
  • Zinc

[2]

Physical Therapy Management (current best evidence)

Goals and Expected Outcomes
  • Decrease pain
  • Decrease joint swelling or inflammation
  • Increase or maintain strength
  • Improve joint integrity and stability
  • Improve range of motion
  • Improve endurance for functional activities
  • Independence for ADL’s
  • Safe and efficient gait
  • Improve functional mobility
  • Increase in quality of life
  • Self management

Interventions:

  • Range of Motion/ Flexibility: Range-of-motion exercises and exercise programs can delay the loss of joint function and help keep muscles strong.
  • Modalities: Heat, ice, massage, ultrasound, hydrotherapy, and electrical stimulation may be used to reduce pain and improve joint movement.
  • Joint protection: Assistive devices, splints or orthotic devices to support and align joints may be very helpful.
  • Energy Conservation: Frequent rest periods between activities, as well as 8 to 10 hours of sleep per night, are recommended.
  • Aerobic Endurance: aerobic capacity/endurance conditioning,
  • Therapeutic exercise: gait training, aquatic programs, range of motion techniques, stretching, strength, power and endurance training
  • Functional Training: ADLs, task adaptation, injury prevention
  • Manual Therapy: passive range of motion, soft tissue mobilization
  • Patient Education
  • Lifestyle changes (Physical activity, dietary, and emotional changes)

[1][5]

ACSM’s Exercise Management for Persons with Chronic Diseases and Disabilities Exercise Prescription
Benefit Type Prescription
CV Health Cycling, walking, swimming, dance 60-80% HR Max, 30-60 min/session, 3-5 days a week; Increase duration, then intensity over time
Muscle Mass and Strength Free weights, weight machines, therabands  60-80% 1RPM, 8-10 exercises (large muscle groups), 8-12 repetitions, 2-3 sets, increase intensity over time
ROM and Flexibility  Stretching, Tai Chi, Yoga/Pilates 10-15 minutes, 2 days a week
Balance One leg stance, stability ball, strengthening core muscles Regular basis

[3]

Adult Rheumatoid Arthritis Physical Therapy Practice Patterns

4A: Primary Prevention/Risk Reduction for Skeletal Demineralization (low bone density)
4B: Impaired Posture (cervical involvement)
4C: Impaired Muscle Performance
~4D: Impaired Joint Mobility, Motor Function, Muscle Performance, and Range of Motion Associated with Connective Tissue Dysfunction
4H: Impaired Joint Mobility, Motor Function, Muscle Performance, and Range of Motion Associated with Joint Arthroplasty
4I: Impaired Joint Mobility, Motor Function, Muscle Performance, and Range of Motion Associated with Bony or Soft Tissue Surgery ( tenosynovectomy, tendon reconstruction)
5H: Impaired Motor Function, Peripheral Nerve Integrity, and Sensory Integrity Associate with Nonprogressive Disorders of the Spinal Cord (cervical spine)
6B: Impaired Aerobic Capacity/Endurance Associated with Deconditioning
~Most Commonly used practice pattern for RA

[10]

Management of flare ups:
People who are diagnosed with RA also may experience a phenomenon that is called an “flare up” of the condition. Research suggests that these flare ups usually happen after experiencing a secondary illness, being involved in a high stress situation, overexerting oneself, . What triggers flare ups is currently still unknown. Current evidence suggests some strategies that can help someone who is experiencing a flare up by reducing pain, inflammation, and improve their quality of life:

  • Balance is key, schedule plenty of down time to reduce the likelihood of affected joints from becoming flared up
  • Educate family, staff at work, and other people who you interact with, they can help you during flare ups
  • Have a backup plan, be prepared in case of a flare up and become familiar with warning signs of a flare up
  • Practice relaxation and self calming strategies: Research suggests that regularly practicing these relaxation techniques can reduce stress and lead to a reduction in pain.
  • Use modalities such as a cold pack or hot pack: Both of these have various effects on tissues which research suggests can be beneficial in reducing inflammation and pain during a flare up
  • Lastly, corticosteroid injections can be used to reduce inflammation and reduce pain in a flared up joint

[2]

Outcome Measures

  • Rheumatoid Arthritis Disease Activity Index (RADAI-5): A self-reported outcome measure that consists of 5 questions in a Likert scale format that briefly surveys the patient regarding their views of their condition (both over the past 6 months and current status).
  • Disabilities of the Arm, Shoulder and Hand (DASH): The DASH is a patient-reported outcome measure that evaluates function of the upper extremities, and can be used to examine change over time.
  • Short Form-36 (SF36): A patient reported outcome measure that is designed to evaluate quality of life through measures such as physical functioning, role limitations due to physical or emotional problems, and general mental health.
  • Fatigue Severity Scale: A 9-item questionnaire that rates the patient’s fatigue and how it interferes with activities such as work or social life.

[4] [5]

Video For PT Management of RA:

Visit - https://youtu.be/LsRd3lg93Pw

Case Study
Key words: Rheumatoid arthritis, physical therapy, DMARD

Authors: Riley Sturzebecher, Lucas Nare

Abstract: Patient is a 36 year old female who presents to PT with bilateral hand and unilateral L elbow pain, bilateral MCP joint swelling, morning stiffness, and increase fatigue. Patient was evaluated and referred to rheumatologist; patient returned to PT with diagnosis of rheumatoid arthritis. Treatment strategies included education on disease process and management as well as an individualized strength and conditioning program with modalities included for pain management. Along with physical therapy, patient was taking a prescription dose of Plaquenil daily in addition to a corticosteroid injection during severe flare-ups. Patient was seen 2x/week for a total of 6 weeks. At discharge, patient reported decrease in max pain from 7/10 on VAS to 3/10, and her Fatigue Severity Scale-9 score decreased from 35/63 to 20/63. Patient was given information about community resources and plans to begin yoga class 3x/week. Follow-up with patient planned at 3 and 6 months post discharge.
Introduction:
Rheumatoid arthritis (RA) is a rare form of arthritis that differs greatly from a more widely known diagnosis of osteoarthritis (OA). Both forms lead to the degeneration of the of articular tissue in many joints of the body but go about the process differently. However, RA will be our main discussion point for this case study. Rheumatoid arthritis is typically described as a systemic autoimmune disease that leads to inflammation of various joints of the body, specifically hands, feet, and wrists. Furthermore, this disease does not only affect the articular cartilage, it can affect surrounding tendons, synovium, and various other structures around the joint. RA S&S include but are not limited to stiffness of affected joints in the morning, fatigue, weakness, joint swelling/tenderness, warm to the touch joints, loss of mobility of affected joints. Furthermore, advanced RA can lead to deformities of the hands, wrists, and feet which can become irreversible. RA is not curable at this time but can be treated with a variety of prescription drugs, injections, and physical therapy. Presented below is a sample case study which demonstrates how a patient may present with RA.
Case Presentation:
Mrs. Smith is a 36 year old female that presents to the clinic with complaints of bilateral hand and unilateral L elbow pain. She was referred from her primary physician with the referral for “Eval and treat”. Patient reported that her doctor ordered x-rays of her hands but wanted her to come to physical therapy as well. Patient states that she has a hard time moving her fingers in the morning but “loosens up” after 30 minutes. Patient explained that she has noticed that she begins to experience fatigue much quicker than she typically would while riding her bike through her neighborhood. Patient states that she is currently not on any medications at this time. Patient reports her past medical history to be the following:
● ACL reconstruction in 9th grade
● Tubes in ears as infant
● Gastric ulcers


Clinical Impression:

Objective findings:
Patient presents with bilateral swelling of hands especially around her MCP joints. The joints are warm, red, and tender to the touch bilaterally. Patient has decreased ROM of MCP joints bilaterally but all other ROM of UE and LE are within normal limits. Patient demonstrated decreased grip strength bilaterally.
Hand pain reported ranging from 2-7 out of 10 on Visual Analogue scale, elbow pain at 4/10 with activity.
Patient scored as 35/63 on Fatigue Severity Scale-9.

Patient was referred out to a rheumatologist to rule out any underlying disease that may be causing her these signs and symptoms. The patient returns to physical therapy with the diagnosis of RA. Rheumatoid factor was found to be positive along with substantial swelling of soft tissue and a loss of bone density were found on the x-ray of her hands. Patient resumes physical therapy, prescribed DMARDs from her doctor, and educated on the progression of RA and treatment options available.

Intervention:
● Patient education to include joint protection strategies or devices if necessary, energy conservation techniques, and lifestyle changes (physical activity levels, diet, etc)
○ Educated on use of NSAIDs for pain management and potential negative side effect with gastric ulcers
● Stretching and mobility exercises: Flexor digiti superficialis and profundus tendon gliding exercises; 2x10 repetitions daily.
● Strengthening:
○ Resisted gross and pinch grip with theraputty: 2x10 repetitions, gradually increase hold time to 5 seconds.
○ Finger and thumb adduction/abduction with putty and theraband.
○ Eccentric wrist strengthening with theraband (especially for L elbow pain)
○ 60-80% of 1 rep max (1RPM) for 8-12 reps
● Aerobic conditioning: Cycling at 60-80% of patient’s HR max, working on increasing duration then intensity.
○ Patient was also educated on use of Rating of Perceived Exertion scale and instructed to maintain a range of 12-13 (moderate to somewhat hard) for home exercise.
● Emotional support resources
● Functional training: Training the patient how to perform ADL’s (activities of daily living) properly and to accommodate mobility limitations and reduce the potential for chronic pain.
● Modalities: using hot packs, cold packs, hydrotherapy, ultrasound, and electrical stimulation to reduce joint plan and inflammation.
● Expose patient to community resources such as yoga, tai chi, and cycling classes
● Co-interventions: Pt is currently taking Plaquenil (DMARD) tablets to help manage her RA, and receives a prednisone injection during flare-ups.

Outcomes:
Mrs. Smith demonstrated an improvement over several months. Mrs. Smith’s therapy involved a multidisciplinary team approach to empower her to understand and treat her RA. The Fatigue Severity Scale-9 was completed at discharge and equalled 20/63 which is a significant improvement from her initial evaluation (35/63). Mrs. Smith was able to return to biking around her neighborhood with little fatigue. Since she was educated on the RA and how the disease progresses, Mrs. Smith is able to stay tune with her body by understanding her limitations and not overdoing any physical activity. Mrs. Smith knows some of her signs and symptoms of a flare up and addresses it appropriately. She continues to utilize modalities at home such as heat and ice to reduce her pain and inflammation when needed. She has also been educated on her current medications, she has been taught what they do, why they are important to take regularly, some of the potential side effects of the medications, and when she should contact her doctor if she thinks an adverse event is taking place. Mrs. Smith has been educated on community support groups that could potentially provide some assistance in the following years. Mrs. Smith has been given and shown many exercises that will improve/sustain her mobility in her hand and reduce pain and inflammation. Now that Mrs. Smith has been educated on RA and given the tools to manage her RA on her own. She was discharged but periodical follow ups were recommended at 3 and 6 months post discharge.

Discussion:
RA currently has no cure, which means Mrs. Smith needs to constantly manage and be aware of her disease at all times. She will more than likely have this disease for the majority of her life so therefore making sure that she has the appropriate tools and education to combat this disease on her own is crucial to remain active and promote the highest quality of life possible.

Related Pages:
1. American College of Rheumatology Patient Education
http://www.rheumatology.org/
2. Physiopedia
http://www.physio-pedia.com/RA_(Rheumatoid_Arthritis)

References:

1. Durstine JL, Moore GE, Painter PL, Roberts SO. ACSM’s Exercise Management for Persons with Chronic Diseases and Disabilities. 2003
2. Goodman CC, Snyder TEK. Differential diagnosis for physical therapists screening for referral. St. Louis, MO: Saunders Elsevier; 2013.

Differential Diagnosis

A) Fibromyalgia
B) Lyme Disease
C) Myelodysplastic syndrome
D) Osteoarthritis
E) Paraneoplastic syndrome
F) Polychondritis
G) Polymyalgia Rheumatica
H) Psoriatic arthritis
I) Sarcoidosis
J) Sjogren Syndrome
K) Systemic Lupus Erythematous

L) Reiter Syndrome
M) Gout

[6][7][8][9]

Case Reports/ Case Studies

1. Fischman A, Abeles M, Zanetti M, Weinstein A, Rothfield N. The coexistence of rheumatoid arthritis and systemic lupus erythematosus: a case report and review of the literature. The Journal Of Rheumatology [serial on the Internet. (1981, May), [cited March 3, 2013]; 8(3): 405-415. Available from: MEDLINE.]

2. McKendry R, Huebsch L, Leclair B. Progression of rheumatoid arthritis following bone marrow transplantation. A case report with a 13-year followup. Arthritis And Rheumatism [serial on the Internet. (1996, July), [cited March 3, 2013]; 39(7): 1246-1253. Available from: MEDLINE.]

3. Krishnadas R, Krishnadas R, Cavanagh J. Sustained remission of rheumatoid arthritis with a specific serotonin reuptake inhibitor antidepressant: a case report and review of the literature. Journal Of Medical Case Reports [serial on the Internet. (2011, Mar 19), [cited March 3, 2013]; 5112. Available from: MEDLINE.]

4. Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Alfredsson L, et al. Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Annals Of The Rheumatic Diseases [serial on the Internet. (2003, Sep), [cited March 3, 2013]; 62(9): 835-841. Available from: MEDLINE.]

5. Ben Dhaou B, Boussema F, Aydi Z, Baili L, Kochbati S, Rokbani L. [Rheumatoid arthritis in the elderly: ten cases report. La Tunisie Médicale [serial on the Internet]. (2012, June), [cited March 3, 2013]; 90(6): 442-445. Available from: MEDLINE.]

6. Källberg H, Jacobsen S, Bengtsson C, Pedersen M, Padyukov L, Alfredsson L, et al. Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies. Annals Of The Rheumatic Diseases [serial on the Internet. (2009, Feb), [cited March 3, 2013]; 68(2): 222-227. Available from: MEDLINE.]

Resources

1. Rheumatoid Arthritis: Help to understand Rheumatoid Arthritis:
http://www.rheumatoidarthritis.com/ra/diagnosing-ra/default.htm
2. Rheumatoid Arthritis: Frequently asked Questions:
http://www.rheumatoidarthritis.com/ra/additional-resources/faq.htm
4. Rheumatology Check List Visit
http://www.rheumatoidarthritis.com/ra/WebResources/pdf/VisitChecklist.pdf
5. The RA Symptom Tracker Sheet
http://www.rheumatoidarthritis.com/ra/WebResources/pdf/SymptomTracker.pdf
6. The Arthritis Organization
http://www.arthritis.org
7. American College of Rheumatology Patient Education
http://www.rheumatology.org/

8.Self-help

http://www.aidsforarthritis.com/
9. RA Treatment

 http://www.ra.com/ra-treatment.aspx

10. American College of Rheumatology

http://www.rheumatology.org

Recent Related Research (from Pubmed)

see tutorial on Adding PubMed Feed

References 

  1. 1.0 1.1 1.2 1.3 1.4 1.5 National Center for Biotechnology Information, U.S. National Library of Medicine. Disease fact sheet:http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001467/ (accessed 1 March 2013)
  2. 2.0 2.1 2.2 2.3 2.4 Arthritis Foundation. Disease fact sheet: http://www.arthritis.org/conditions-treatments/disease-center/rheumatoid-arthritis/ (accessed 25 February 2013).
  3. 3.0 3.1 3.2 CDC. Rheumatoid Arthritis.http://www.cdc.gov/arthritis/basics/rheumatoid.htm (accessed 13 February 2013).
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Mayo Clinic. Disease fact sheet: rheumatoid arthritis. http://www.mayoclinic.com/health/rheumatoid-arthritis/DS00020 (accessed 12 February 2013)
  5. 5.0 5.1 5.2 5.3 5.4 5.5 O’Sullivan and Schmitz. Physical Rehabilitation. 5th edition. Philadelphia, PA: F.A. Davis Company. 2007.
  6. 6.0 6.1 Pubmed. Comorbidities in rheumatoid arthritis. http://www.ncbi.nlm.nih.gov/pubmed/17870034 (accessed 12 February 2013).
  7. 7.0 7.1 Gabriel SE. Cardiovascular morbidity and mortality in rheumatoid arthritis. Am J Med. 2008 Oct;121(10 Suppl 1):S9-14.
  8. 8.0 8.1 8.2 Medicine Plus: Rheumatoid Arthritis. http://www.nlm.nih.gov/medlineplus/ency/article/000431.htm (accessed 1 March 2013)
  9. 9.0 9.1 eMedicine. Disease fact sheet: rheumatoid arthritis. http://emedicine.medscape.com/article/409980-overview (accessed 10 March 2013).
  10. 10.0 10.1 Firestein GS. . Etiology and pathogenesis of rheumatoid arthritis. In: Harris ED, Budd RC, Genovese MC, Firestein GS, Sargent JS, Sledge CB, eds. Kelley's Textbook of Rheumatology. 7th ed. Philadelphia, Pa: Saunders Elsevier; 2005:chap 65.
  11. Goodman C, Fuller K. Pathology: Implications for the Physical Therapist. 3rd ed. . St. Louis, MO: Saunders, an imprint of Elsevier Inc, 2009.