Pellegrini-Stieda syndrome

Definition/Description[edit | edit source]

Pellegrini-stieda syndrome is a condition in which a calcification occurs on the medial side of the knee. This calcium deposit develops between the attachment of the medial collateral ligament and medial condyle.
[1, 6, 13]

Clinically Relevant Anatomy[edit | edit source]

The medial collateral ligament (MCL)[attachment 3] is a broad, flat band that extends from the medial femoral epicondyle to the medial meniscus, tibial plateau, and adjacent shaft. It consists of superficial and deep components. The superficial component attaches distally to the medial aspect of the tibia and proximally to the medial femoral epicondyle. The deeper component originates from the medial joint capsule and attaches to the medial meniscus.


The superficial component is about 10 cm long and flat. The bursae separate the capsule and the medial meniscus of the superficial component. It may be one or more bursae. The superficial component of the medial collateral ligament crosses, in his way down to the medial site and posterior medial surface of the tibial, the tendons of the sartorius, gracilis and, semitendinosus, also separated by a bursa. Below the ligament runs the medial inferior geniculi vessels and nerve and the anterior section of the semimembranosus tendon. The deeper component is shorter than the superficial and descends posteriorly to the medial tibial plateau, proximal to the groove for the semimembranosus.


The medial collateral ligament is an important ligament, it has an important role in stabilizing the knee joint. The long fibers of the MCL primarily stabilize the medial side of the knee against valgus and external rotatory stress. The deeper part of this ligament also helps the anterior cruciate ligament in avoiding an anterior translation of the tibia on the femur.
[2, 3, 9]



Epidemiology /Etiology[edit | edit source]

The Pellegrini-stieda syndrome is a relatively infrequent phenomenon. It is commonly associated with sporting injuries.
[5, 6]

What about the etiology of the condition?
The cause of the Pellegrini-Stieda syndrome is an injury to the attachment site of the medial collateral ligament to the medial condyle of the femur. This usually occurs after a direct trauma to the site, like for instance a hit on the inside of the knee with a ball at high speed or after an overstretching injury to the medial collateral ligament and joint capsule.
The mechanism can develop a hematoma or inflammatory edema as a result of tearing and shredding fibers at their femoral attachment7. The soft tissues degenerate and become affected, forming a place for deposition of calcium salts. After a while, the phenomena could occur: the inflammation subsides with partial or complete resorption of the calcium salts, or the mass becomes ossified and may be connected by a pedicle to the femoral condyle. The last is called Pellegrini-Stieda syndrome.
[5, 7]


Characteristics/Clinical Presentation[edit | edit source]

The term ‘Pellegrini-Stieda’ is only reserved for the few patients who are symptomatic; most of the patients with post traumatic calcification of the proximal aspect of the MCL are indeed asymptomatic. Pellegrini-Stieda disease is characterized by formation of a soft tissue edema followed by the formation of a dense, calcific infiltration of the swelling on the medial side of the knee. This happened within 11 days to 6 weeks after post trauma.6 (level of evidence 5) A network of new bone formation around the periphery of the mass of the medial condyle is formed in 6 to 8 weeks.6 Duration of the condition is usually about 5 to 6 months.6
Pain and local swelling are the two first symptoms following an injury like traumatic synovitis. There will be no full recovery from this injury, yet there will be symptomatic improvement. The pain and disability will increase after a few weeks or months. The knee will be stiff with limitation of movement and pain over the medial side of the knee. The stiffness in the knee will mainly hamper the stretching of the knee but also twisting of the knee will be rather difficult. In addition to the limitation of motion, it is possible that a tender lump can be seen on the inside of the knee.
[4, 6, 8, 11]

Differential Diagnosis[edit | edit source]

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Diagnostic Procedures[edit | edit source]

Prognosis

When a full range of motion in the knee is attained, and the athlete does not feel any form of pain, he can resume his activities. It is also important that the range of motion is symmetric on both sides. Also the muscles, Quadriceps and Hamstrings, have fully recovered. This means full power recovery.
[4, 13]

Outcome Measures[edit | edit source]

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Examination[edit | edit source]

The patient complains about a severe, recurrent pain in the inner aspect of the knee.11 Most of the patients sustained an injury years, months or weeks earlier.1,11 The gait of the patient is normal with mild tenderness over de medial border of the knee.11 In most of the cases, on examination no swelling can be observed.1 The patient has some difficulty with full passive extension or twisting of the knee. There is no ligamentous laxity.11
[1, 11]

Medical Management
[edit | edit source]

The use of Aspirin or non-steroidal anti-inflammatory preparations could be prescribed in the treatment of this condition. And if pain persists is infiltration of a corticosteroid agent to the tender medial collateral ligament attachment useful.
[6, 12]

In some cases, the patients undergo surgery. There are good results after treatment of Pellegrini-Stieda syndrome. The pain is gone and the knee again has his full range of motion.
[14]


Physical Therapy Management
[edit | edit source]

First conservative work, with emphasis on avoiding overload and microtrauma. For example forced rehabilitation or early sports resumption is to be avoided. Ice therapy is useful, as well as local and general antiflogistica.10(level of evidence 5) Even conservative rehabilitation and mobilization of the knee joint are necessary. The different steps of the functional rehabilitation can be completed, only in a more controlled and slow manner.10
Some examples of knee bending exercises are heel slides, seated knee bending, seated chair slides and knee bending on stomach. To increase the stretch you can use a strap around your ankle and pull or use your other leg to pull. Knee straightening exercises are in lying or sitting position with a towel roll under your ankle so that your calf clears the table, you increase the stretch. You also can do knee straightening on stomach, you have to put the towel roll under the thigh and the feet off the edge of the table.15
[10, 11, 12, 15]

Key Research[edit | edit source]

Pellegrini-Stieda syndrome, Pellegrini-Stieda disease, ossification medial collateral ligament, knee injuries, limited range of motion knee.

Resources
[edit | edit source]

- Pubmed
- Web of knowledge
- Books

Clinical Bottom Line[edit | edit source]

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Recent Related Research (from Pubmed)[edit | edit source]


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References[edit | edit source]

1. Peter brukner and Karim Khan, Third edition (2006), Clinical sports medicine, p.549.
Opgezocht: 29/11/2011

2. Adam B. Agranoff MD, Medial collateral and lateral collateral ligament injury, (1994-2011).
Opgezocht: 27/10/2011, Link: http://emedicine.medscape.com/article/307959-overview

3. Dr. Sheila Strover, Knee guru information hub, anatomy of the collateral ligaments, (2011).
Opgezocht: 27/10/2011, Link: http://www.kneeguru.co.uk/KNEEnotes/node/881

4. Vinzendi, medisch advies bureau, (2006-2011)
Opgezocht: 27/10/2011, Link: http://www.sportkeuringen.com/index.php?option=com_content&view=article&id=136:knie-pellegrini-stieda-syndroom&catid=22:knie-klachten&Itemid=66

5. Andy C., Wiki Radiography, world’s largest radiography encyclopedia, Pellegrini-Stieda disease, (2010). Opgezocht: 29/10/2011, Link: http://www.wikiradiography.com/page/Pellegrini-Stieda+Disease

6. PL Kogon, Jerry Tchoryk, Owen Fleming, Pellegrini-stieda disease.
Opgezocht: 01/11/2011, Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2484441/pdf/jcca00068-0025.pdf
Level of evidence: 5

7. John W. Turner, Ibrahim B. Syed, and Richard P. Spencer,Two unusual causes of peripatellar nonmetastatic positive bone scans in patients with malignancies: case reports.
Opgezocht: 01/11/2011, Link: http://www.ncbi.nlm.nih.gov/pubmed/932812
Level of evidence: 5

8. Pellegrini-stieda’s disease, post-traumatic para-articular osteoma
Opgezocht: 01/11/2011, Link: http://www.patscotland.org.uk/medical_appendices/P/PELLEGRINI-STIEDA'S%20DISEASE.pdf

9. Schunke
 M., Schulte
 E.,
 Schumacher, tweede druk (2010). Anatomische atlas
 Prometheus:
 Algemene anatomie en bewegingsapparaat.
Nederland:
Bohn Stafleu Van Loghum.

10. Prof. Dr. R. Meeusen , Vrije universiteit brussel, cursus 488, (2011).
Opgezocht: 19/11/2011

11. Akinpelu M., Vijayvargiya S., Prakash C., Kayode M., Awosanya G., Internet scientific publications (LLC, 1996-2011).
Opgezocht: 26/11/2011, Link: http://www.ispub.com/journal/the-internet-journal-of-radiology/volume-12-number-2/pellegrini-stieda-syndrome-report-of-two-cases.html
Level of evidence: 5

12. Eric L. Altschulder, M.D., Ph.D. and Thomas N. Bryse M.D., MT., Sinai school of medicine, New York, The new england journal of medicine, Pellegrini-stieda syndrome, (2011).
Opgezocht: 01/11/2011, Link: http://www.nejm.org/doi/full/10.1056/NEJMicm040406
Level of evidence: 5

13. V Shiv Shanker, S. Gadikoppula, M D Loeffler, Post traumatic osteoma of tibial insertion of medial collateral ligament of the knee joint.
Opgezocht: 01/11/2011, Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1756070/pdf/v032p00073.pdf
Level of evidence: 5

14. Kanthan Theivendran, Caroline J. Lever, William J. Hart, Good result after treatment of Pellegrini-Stieda syndrome.
Opgezocht: 02/12/2011, Link: http://www.springerlink.com/content/k8v74172p5912522/fulltext.pdf
Level of evidence: 3b

15. The permanente Mediacal Group, regional health education and physical therapy, tips and exercises for your knee stiffness and pain, 2009.
Opgezocht: 22/12/2011, Link: http://www.permanente.net/homepage/kaiser/pdf/64676.pdf

16. Lephart SM, Henry TJ, functional rehabilitation for the upper and lower extremity, department of Orthopaedic surgery of Pitgtsburg, Pennsylvania, USA.
Opgezocht: 25/12/2011, Link: http://www.ncbi.nlm.nih.gov/pubmed/7609967