Vitamin D and the Effect on Mental Health: Difference between revisions
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Calcitrol is the active Vitamin D hormone, which affect the neurotransmitters and neurotrophic factors that may lead to mental disorders. Vitamin D receptors and metabolites are present in the Central Nervous System. Vitamin D deficiency can be a cause for mental disorders. <ref name=":0" /> | Calcitrol is the active Vitamin D hormone, which affect the neurotransmitters and neurotrophic factors that may lead to mental disorders. Vitamin D receptors and metabolites are present in the Central Nervous System. Vitamin D deficiency can be a cause for mental disorders. <ref name=":0" /> | ||
== Calcitrol == | == Calcitrol and Vitamin D == | ||
The main function of calcitrol is its involvement with the synthesis and degradation of neurotransmitters, plays an important role in regulating various neurotrophic factors, and is an antioxidative defense mechanism for the brain. | The main function of calcitrol is its involvement with the synthesis and degradation of neurotransmitters, plays an important role in regulating various neurotrophic factors, and is an antioxidative defense mechanism for the brain. <ref name=":0" /> | ||
Calcitrol binds to a specific ligand, the Vitamin D receptor (VDR), which affects the gene expression of various target genes. VDR is located within the Central Nervous System (CNS), and the necessary enzymes and receptors spread throughout the human brain. the Vitamin D endocrine system acts within the CNS. | Calcitrol binds to a specific ligand, the Vitamin D receptor (VDR), which affects the gene expression of various target genes. VDR is located within the Central Nervous System (CNS), and the necessary enzymes and receptors spread throughout the human brain. the Vitamin D endocrine system acts within the CNS. <ref name=":0" /> | ||
Calcitrol activates the gene expression of tyrosine hydroxylase, which increases the use of dopamine, adrenaline, and noradrenaline. It may advance the activation of cholinergic function, accelerating the activity f choline acetyltransferase and reducing the activity of acetylcholine esterase. | Calcitrol activates the gene expression of tyrosine hydroxylase, which increases the use of dopamine, adrenaline, and noradrenaline. It may advance the activation of cholinergic function, accelerating the activity f choline acetyltransferase and reducing the activity of acetylcholine esterase. | ||
Calcitriol helps enhance nerve growth factor (NGF) and glial derived neurotrophic factor (GDNF). It also helps increase the activity of neurotrophin-3 (NT-3), and decrease neurotrophin-4 (NT-4). NGF is important for the prenatal development of the brain, and it may prevent degradation of the cholinergic system in Alzheimer’s disease. It can be noted that NGF, NT-3 and GDNF can be factors for depression and schizophrenia. GDNF can act as a treatment with Parkinson's Disease, and dependence disorders. | Calcitriol helps enhance nerve growth factor (NGF) and glial derived neurotrophic factor (GDNF). It also helps increase the activity of neurotrophin-3 (NT-3), and decrease neurotrophin-4 (NT-4). NGF is important for the prenatal development of the brain, and it may prevent degradation of the cholinergic system in Alzheimer’s disease. It can be noted that NGF, NT-3 and GDNF can be factors for depression and schizophrenia. GDNF can act as a treatment with Parkinson's Disease, and dependence disorders. <ref name=":0" /> | ||
Vitamin D defends the brain against oxidative damage. | Vitamin D defends the brain against oxidative damage. It increases the gene expression of the enzyme aiding in the function of the most important antioxidant in the brain, glutathione, and helps increases the levels of this antioxidant. <ref name=":0" /> | ||
It is seen that alterations in the Vitamin D supply in the brain, can interfere with brain functions directed to psychiatric and neuropsychiatric behaviours. There can be disorders developed on a seasonal basis. The lack of vitamin D exposure can lead to a delay in early rain development, and even brain degeneration in the elderly. <ref name=":0" /> | |||
== Seasonal Disorders == | |||
Depressive Disorder | |||
== Possible Negative Effects == | == Possible Negative Effects == | ||
Revision as of 20:19, 30 June 2024
Original Editor - Kapil Narale
Top Contributors - Kapil Narale
Introduction[edit | edit source]
It is known that sunlight, warm temperatures, and the spring and summer seasons are associated with positive feelings and happiness. Dark, gloomy environments, associated with misery and fear, was associated with rickets. This is when Vitamin D was discovered. Vitamin D was discovered and identified in the 1920s. This was used as a remedy and treatment for rickets, which occurred with minimal sunlight exposure. As a prevention measure more sunlight exposure was needed. The prevention of rickets, encouraged the necessity of increased sunlight exposure. [1]
Calcitrol is the active Vitamin D hormone, which affect the neurotransmitters and neurotrophic factors that may lead to mental disorders. Vitamin D receptors and metabolites are present in the Central Nervous System. Vitamin D deficiency can be a cause for mental disorders. [1]
Calcitrol and Vitamin D[edit | edit source]
The main function of calcitrol is its involvement with the synthesis and degradation of neurotransmitters, plays an important role in regulating various neurotrophic factors, and is an antioxidative defense mechanism for the brain. [1]
Calcitrol binds to a specific ligand, the Vitamin D receptor (VDR), which affects the gene expression of various target genes. VDR is located within the Central Nervous System (CNS), and the necessary enzymes and receptors spread throughout the human brain. the Vitamin D endocrine system acts within the CNS. [1]
Calcitrol activates the gene expression of tyrosine hydroxylase, which increases the use of dopamine, adrenaline, and noradrenaline. It may advance the activation of cholinergic function, accelerating the activity f choline acetyltransferase and reducing the activity of acetylcholine esterase.
Calcitriol helps enhance nerve growth factor (NGF) and glial derived neurotrophic factor (GDNF). It also helps increase the activity of neurotrophin-3 (NT-3), and decrease neurotrophin-4 (NT-4). NGF is important for the prenatal development of the brain, and it may prevent degradation of the cholinergic system in Alzheimer’s disease. It can be noted that NGF, NT-3 and GDNF can be factors for depression and schizophrenia. GDNF can act as a treatment with Parkinson's Disease, and dependence disorders. [1]
Vitamin D defends the brain against oxidative damage. It increases the gene expression of the enzyme aiding in the function of the most important antioxidant in the brain, glutathione, and helps increases the levels of this antioxidant. [1]
It is seen that alterations in the Vitamin D supply in the brain, can interfere with brain functions directed to psychiatric and neuropsychiatric behaviours. There can be disorders developed on a seasonal basis. The lack of vitamin D exposure can lead to a delay in early rain development, and even brain degeneration in the elderly. [1]
Seasonal Disorders[edit | edit source]
Depressive Disorder
Possible Negative Effects[edit | edit source]
With an increased exposure to sunlight and solar radiation, there is a possibility of skin cancer, especially malignant melanoma, in the long term. With the change of minimsing exposure to sunlight, there was a noted increased prevalence of major depressive disorder in the US and Europe, especially among children and adolescents. There can also be an increased prevalence of autism spectrum disorder. [1]
Resources[edit | edit source]
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