Transverse Myelitis: Difference between revisions

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*Clearly defined sensory level
*Clearly defined sensory level


The symptoms of TM include muscle weakness, paralysis, parasthesia, neuropathic pain, spasticity, as well as bladder, bowel and sexual dysfunction. - See more at: http://www.myelitis.org.uk/symptoms-and-diagnosis.html#sthash.ZRv8wney.dpuf
The symptoms of TM include muscle weakness, paralysis, parasthesia, neuropathic pain, spasticity, as well as bladder, bowel and sexual dysfunction.


There is tremendous variability in the presentation of symptoms, which are based on the level of the spinal cord affected and on the severity of the damage to the myelin and the neurons in the spinal cord.  
There is tremendous variability in the presentation of symptoms, which are based on the level of the spinal cord affected and on the severity of the damage to the myelin and the neurons in the spinal cord.


== Diagnostic Procedures  ==
== Diagnostic Procedures  ==

Revision as of 22:32, 26 July 2015

Original Editor - Wendy Walker

Lead Editors  Wendy Walker

Introduction
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Transverse Myelitis (TM), AKA Acute Transverse Myelitis (ATM) is a rare neurological disorder of the spinal cord, caused by inflammation and occurring across one spinal segment, leading to severe motor, sensory and autonomic dysfunction[1].

The incidence of TM is 1 (severe) to 8 (mild) cases/million per year[2].

The term Transverse Myelitis (TM) was first coined in 1948 by Dr Suchett-Kaye, an English neurologist. He uses this to describe a case of rapidly progressive paraparesis with a thoracic sensory level, occurring as a post-infectious complication of pneumonia.

Mechanism of Injury / Pathological Process
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The mechanism of injury is inflammation of the spinal cord causing damage to the myelin sheath of the nerves.

Clinical Presentation[edit | edit source]

  • Sensory, motor, or autonomic dysfunction attributable to the spinal cord
  • Bilateral signs and/or symptoms
  • Clearly defined sensory level

The symptoms of TM include muscle weakness, paralysis, parasthesia, neuropathic pain, spasticity, as well as bladder, bowel and sexual dysfunction.

There is tremendous variability in the presentation of symptoms, which are based on the level of the spinal cord affected and on the severity of the damage to the myelin and the neurons in the spinal cord.

Diagnostic Procedures[edit | edit source]

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Outcome Measures[edit | edit source]

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Management / Interventions
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Differential Diagnosis
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The most common etiologies to be distinguished from idiopathic acute transverse myelitis are:

Multiple Sclerosis

parainfectious myelitis

NMO (Devic's disease)

myelitis related to systemic disease, such as systemic lupus erythematosis

Key Evidence[edit | edit source]

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Resources
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Case Studies[edit | edit source]

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Recent Related Research (from Pubmed)[edit | edit source]

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References[edit | edit source]

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  1. Proposed diagnostic criteria and nosology of acute transverse myelitis. Neurology. 2002;59 (4): 499-505
  2. Berman M, Feldman S, Alter M, Zilber N, Kahana E. Acute transverse myelitis: incidence and etiologic considerations. Neurology 1981;31:966–971