Pigmeted Villonodular Synovitis: Difference between revisions
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Databases: <br>• PubMed<br>• Web of Knowledge (Web of Science)<br>• Books<br>• Internet<br><br>Keywords: <br> • (Localized/Diffuse) Pigmented Villonodular Synovitis<br>• Treatment<br>• Physiotherapy (Physical Therapy)<br>• Postoperative Therapy<br><br>Time Line: <br> • 2000 – 2011<br> | Databases: <br>• PubMed<br>• Web of Knowledge (Web of Science)<br>• Books<br>• Internet<br><br>Keywords: <br> • (Localized/Diffuse) Pigmented Villonodular Synovitis<br>• Treatment<br>• Physiotherapy (Physical Therapy)<br>• Postoperative Therapy<br><br>Time Line: <br> • 2000 – 2011<br> | ||
== Definition/Description == | == Definition/Description == |
Revision as of 21:25, 25 September 2012
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Search Strategy[edit | edit source]
Databases:
• PubMed
• Web of Knowledge (Web of Science)
• Books
• Internet
Keywords:
• (Localized/Diffuse) Pigmented Villonodular Synovitis
• Treatment
• Physiotherapy (Physical Therapy)
• Postoperative Therapy
Time Line:
• 2000 – 2011
Definition/Description[edit | edit source]
Pigmented Villonodular Synovitis, also known as PVNS, is a rare idiopathic proliferative disorder of the synovium that leads to villous and or nodular formations within joints, tendon sheaths and bursae [5][6][9]. It affects adults between twenty and sixty years old, independent of the gender [1][12]. It may also uncommonly appear in children [8]. Despite the disease is benign, PVNS can be aggressive, spreading to surrounding synovial tissues and invading adjacent soft tissue structures and bone, resulting in effusions and bony erosion [9][11]. PVNS does not exhibit cellular atypia, but there is recent evidence of cytogenetic abnormalities [5], which may suggest a neoplastic origin [7]. In an early description were three forms of this disease defined [9]: an isolated lesion involving the tendon sheaths (giant cell tumour of the tendon sheath); a solitary intraarticular nodule (localized PVNS); and a diffused villous and pigmented lesion involving synovial tissue (diffuse PVNS) [5]. But more recently, PVNS is subdivided into two forms: isolated nodular lesions (localized form) and those with diffuse joint involvement (diffuse form) [9]. The localized form is also called ‘giant cell tumour of tendon sheath’ [4][8]. Both forms share the same histological characteristics [5][9], but it is essential to distinguish localized from diffuse because their clinical management differ, as do their responses to treatment [4].
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Epidemiology /Etiology[edit | edit source]
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