Klüver-Bucy Syndrome: Difference between revisions

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== Clinically Relevant Anatomy<br> ==
== Introduction ==


add text here relating to '''''clinically relevant''''' anatomy of the condition<br>
'''Klüver-Bucy Syndrome (KBS)''' is a dysfunction arising from lesions of bilateral medial temporal lobes, including nucleus of the amygdala1. Though, it is a neurologic dysfunction. It may also be classified under “psychiatry”. It was first recorded among individuals who had undergone temporal lobectomy in 1955.


== Mechanism of Injury / Pathological Process<br>  ==
The investigation leading to the discovery was carried out by Heinrich Klüver and Paul Bucy, a neurosurgeon on a number of rhesus monkeys in the 1930s.2<br>  
 
add text here relating to the mechanism of injury and/or pathology of the condition<br>  


== Clinical Presentation  ==
== Clinical Presentation  ==


add text here relating to the clinical presentation of the condition<br>
Clinical presentations are not agreed upon and vary in literature according to source. Generally, it includes the following;345


== Diagnostic Procedures  ==
* Amnesia; this is essentially inability to recall past experiences (memories) which may be anterograde – inability to recall events from the period of the amnesic episode, or retrograde – loss of memory from the period before the amnesic episode.
* Tameness; also termed “placidity” or “docility”, it is characterized by showing reduced ‘flight or fight’ response.
* Hyperphagia and dietary changes; this can present as pica (eating inappropriate objects) and/or overeating
* Hyperorality; “oral tendency or compulsion to examine objects by mouth”
* Hypersexuality; manifested as a heightened sex drive and propensity to seek sexual stimulation from unusual and inappropriate objects.
* Visual agnosia; inability to identify familial items and people.


add text here relating to diagnostic tests for the condition<br>


== Outcome Measures  ==
Some presentations which are found to be inconsistent include;


add links to outcome measures here (see [[Outcome Measures|Outcome Measures Database]])
* Hypermetamorphorsis; “an irresistible impulse to notice and react to everything in sight”
* Diminished or lack of emotional response


== Management / Interventions<br> ==
== Diagnostic Procedures ==
It is uncommon for patients to manifest all symptoms, three or more of which is essential for diagnosis. The commonest symptoms in humans include tameness, hyperorality and dietary changes.<br>


add text here relating to management approaches to the condition<br>
== Predisposing Conditions ==
Conditions which predisposes an individual to the diagnosis of KBS include;


== Differential Diagnosis<br> ==
* Temporal lobectomy
* Meningoencephalitis
* Acute herpes simplex encephalitis
* Stroke
* Pick disease
* Alzhemier’s disease
* Ischemia
* Anoxia
* Progressive subcortical gliosis
* Rett syndrome
* Porphyria
* Carbon monoxide poisoning, among others<br>


add text here relating to the differential diagnosis of this condition<br>  
== Management / Interventions<br> ==


== Resources <br>  ==
Studies have shown pharmacotherapy as an effective way of combating KBS with literature on physiotherapy intervention and management very sparse. Pharmacological interventions have been known to include treatment with; 7


add appropriate resources here
* Carbamezine
* Valproate
* Topiramate
* Quetiapine,
* Propranolol
* Benztropine
* Haloperidol
* Trazodone
* Sertraline
* Olanzapine
* Lorazepam
* Valproic acid
* Thiothixene
* Bromocriptine<br>


== References  ==
== References  ==


<references />
<references />

Revision as of 21:58, 25 July 2021

Original Editor - User Name
Top Contributors - Kehinde Fatola, Rucha Gadgil and Cindy John-Chu

Introduction[edit | edit source]

Klüver-Bucy Syndrome (KBS) is a dysfunction arising from lesions of bilateral medial temporal lobes, including nucleus of the amygdala1. Though, it is a neurologic dysfunction. It may also be classified under “psychiatry”. It was first recorded among individuals who had undergone temporal lobectomy in 1955.

The investigation leading to the discovery was carried out by Heinrich Klüver and Paul Bucy, a neurosurgeon on a number of rhesus monkeys in the 1930s.2

Clinical Presentation[edit | edit source]

Clinical presentations are not agreed upon and vary in literature according to source. Generally, it includes the following;345

  • Amnesia; this is essentially inability to recall past experiences (memories) which may be anterograde – inability to recall events from the period of the amnesic episode, or retrograde – loss of memory from the period before the amnesic episode.
  • Tameness; also termed “placidity” or “docility”, it is characterized by showing reduced ‘flight or fight’ response.
  • Hyperphagia and dietary changes; this can present as pica (eating inappropriate objects) and/or overeating
  • Hyperorality; “oral tendency or compulsion to examine objects by mouth”
  • Hypersexuality; manifested as a heightened sex drive and propensity to seek sexual stimulation from unusual and inappropriate objects.
  • Visual agnosia; inability to identify familial items and people.


Some presentations which are found to be inconsistent include;

  • Hypermetamorphorsis; “an irresistible impulse to notice and react to everything in sight”
  • Diminished or lack of emotional response

Diagnostic Procedures[edit | edit source]

It is uncommon for patients to manifest all symptoms, three or more of which is essential for diagnosis. The commonest symptoms in humans include tameness, hyperorality and dietary changes.

Predisposing Conditions[edit | edit source]

Conditions which predisposes an individual to the diagnosis of KBS include;

  • Temporal lobectomy
  • Meningoencephalitis
  • Acute herpes simplex encephalitis
  • Stroke
  • Pick disease
  • Alzhemier’s disease
  • Ischemia
  • Anoxia
  • Progressive subcortical gliosis
  • Rett syndrome
  • Porphyria
  • Carbon monoxide poisoning, among others

Management / Interventions
[edit | edit source]

Studies have shown pharmacotherapy as an effective way of combating KBS with literature on physiotherapy intervention and management very sparse. Pharmacological interventions have been known to include treatment with; 7

  • Carbamezine
  • Valproate
  • Topiramate
  • Quetiapine,
  • Propranolol
  • Benztropine
  • Haloperidol
  • Trazodone
  • Sertraline
  • Olanzapine
  • Lorazepam
  • Valproic acid
  • Thiothixene
  • Bromocriptine

References[edit | edit source]