Persistent Genital Arousal Disorder (PGAD): Difference between revisions

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  '''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}}</div>'''This article or area is currently under construction and may only be partially complete. Please come back soon to see the finished work! (18/3/2023)'''
  '''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}}</div>'''This article or area is currently under construction and may only be partially complete. Please come back soon to see the finished work! (18/3/2023)'''


== Clinically Relevant Anatomy<br>  ==
== Introduction ==


add text here relating to '''''clinically relevant''''' anatomy of the condition<br>  
Persistent genital arousal disorder (PGAD), restless genital syndrome (ReGS), or genitopelvic dysesthesia (GD) a rare disorder defined as persistatant, unpleasant , distressing sensation of unwanted arousal of genetalia, happens in the absence of any arousal or sexual stimulus, dose not resolve by orgasm or masturbation, may last for hours or days, and usually has a negative impact on individual's life. Symptoms may be triggered by sexual cues, non-sexual cues, or it may be idiopathic. Persistent genital arousal disorder (PGAD) was described for the first time in 2001 by Sandra Leiblum and Sharon Nathan<ref>Jackowich RA, Pukall CF. [https://link.springer.com/article/10.1007/s11930-020-00268-2#Sec1 Persistent genital arousal disorder: a biopsychosocial framework.] Current Sexual Health Reports. 2020 Sep;12:127-35.</ref>.


== Mechanism of Injury / Pathological Process<br>  ==
== Mechanism of Injury / Pathological Process ==


add text here relating to the mechanism of injury and/or pathology of the condition<br>  
As it was described for first time 20 years ago and it difficult to know its prevalence there is limited studies about PGAD that are individual case studies till now there is not RCT or SR studies about PGAD how to diagnose, assess, or treat.
 
There are different hypotheses for causes of PGAD that may be multifacorial; vascular factors, central and peripheral nervous system factors, pharmacological factors, psychosocial factors''',''' dietary''',''' or even  idiopathetic factors.
 
'''Pharmacological factors''', it was reported in a few case report studies that drugs that contain serotonergic such as antidepressant medication (SSRIs /SNRIs) may induce or worsen PGAD symptoms <ref>Leiblum SR, Goldmeier D. Persistent genital arousal disorder in women: case reports of association with anti-depressant usage and withdrawal. Journal of Sex & Marital Therapy. 2008 Feb 21;34(2):150-9.</ref>even at initiation or withdrawal of drug, however, there were cases in which there was a fundamental improvement of PGAD symptoms anticonvulsant or SNRI<ref>Kruger TH, Schippert C, Meyer B. The [https://link.springer.com/article/10.1007/s11930-020-00240-0#Sec5 pharmacotherapy of persistent genital arousal disorder]. Current Sexual Health Reports. 2020 Mar;12:34-9.
 
</ref>.


== Clinical Presentation  ==
== Clinical Presentation  ==


add text here relating to the clinical presentation of the condition<br>
Pain or discomfort in the genetalia
 
Tingling around clitoris.


== Diagnostic Procedures  ==
== Diagnostic Procedures  ==
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<references />
<references />
[[Category:Womens Health]]
[[Category:Mens Health]]
[[Category:Mental Health - Conditions]]
[[Category:Pelvic Health]]
[[Category:Pelvis - Conditions]]
[[Category:Psychological Concepts]]

Revision as of 01:18, 25 March 2023

Original Editor - User Name
Top Contributors - Khloud Shreif

This article or area is currently under construction and may only be partially complete. Please come back soon to see the finished work! (18/3/2023)

Introduction[edit | edit source]

Persistent genital arousal disorder (PGAD), restless genital syndrome (ReGS), or genitopelvic dysesthesia (GD) a rare disorder defined as persistatant, unpleasant , distressing sensation of unwanted arousal of genetalia, happens in the absence of any arousal or sexual stimulus, dose not resolve by orgasm or masturbation, may last for hours or days, and usually has a negative impact on individual's life. Symptoms may be triggered by sexual cues, non-sexual cues, or it may be idiopathic. Persistent genital arousal disorder (PGAD) was described for the first time in 2001 by Sandra Leiblum and Sharon Nathan[1].

Mechanism of Injury / Pathological Process[edit | edit source]

As it was described for first time 20 years ago and it difficult to know its prevalence there is limited studies about PGAD that are individual case studies till now there is not RCT or SR studies about PGAD how to diagnose, assess, or treat.

There are different hypotheses for causes of PGAD that may be multifacorial; vascular factors, central and peripheral nervous system factors, pharmacological factors, psychosocial factors, dietary, or even idiopathetic factors.

Pharmacological factors, it was reported in a few case report studies that drugs that contain serotonergic such as antidepressant medication (SSRIs /SNRIs) may induce or worsen PGAD symptoms [2]even at initiation or withdrawal of drug, however, there were cases in which there was a fundamental improvement of PGAD symptoms anticonvulsant or SNRI[3].

Clinical Presentation[edit | edit source]

Pain or discomfort in the genetalia

Tingling around clitoris.

Diagnostic Procedures[edit | edit source]

add text here relating to diagnostic tests for the condition

Outcome Measures[edit | edit source]

add links to outcome measures here (see Outcome Measures Database)

Management / Interventions
[edit | edit source]

add text here relating to management approaches to the condition

Differential Diagnosis
[edit | edit source]

add text here relating to the differential diagnosis of this condition

Resources
[edit | edit source]

add appropriate resources here

References[edit | edit source]

  1. Jackowich RA, Pukall CF. Persistent genital arousal disorder: a biopsychosocial framework. Current Sexual Health Reports. 2020 Sep;12:127-35.
  2. Leiblum SR, Goldmeier D. Persistent genital arousal disorder in women: case reports of association with anti-depressant usage and withdrawal. Journal of Sex & Marital Therapy. 2008 Feb 21;34(2):150-9.
  3. Kruger TH, Schippert C, Meyer B. The pharmacotherapy of persistent genital arousal disorder. Current Sexual Health Reports. 2020 Mar;12:34-9.