The Influence of NSAIDs on Physiologic Processes and Exercise

Introduction

Non-Sterodial Ani-Inflammatory Drugs (NSAIDs), including acetaminophen (Asprin) and Ibuprophen, simply put, reduce inflammation and pain. NSAIDs are widely and commonly used, which is why researchers are countinuously studying the risks and benefits of their effects on the human body. 

NSAIDs work by inhibiting the activity of an enzyme called cycoloxygenase (COX), which is crucial in the formation of prostaglandins. Prostaglandins play a role in the generation of pain and in the inflammatory response; however, they also have roles in many other bodily functions. When NSAID's inhibit prostaglandin synthesis they can reduce pain and inflammation, but they can also hamper gastrointestinal functions and post-exercise protein synthesis, as well as cause a number of other positive and negative side effects. These effects are further discussed for the following body systems: muscular, cardiovascular, metabolic, pulmonary, neuromotor and gastrointestinal. 

Muscular

Cardiovascular

Metabolic

Pulmonary

Neuromotor

Gastrointestinal