Neurogenic inflammation in Musculoskeletal Condition: Difference between revisions
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
Fine unmyelinated afferent somatic C-fibers, which respond to low intensity mechanical and chemical stimulations, are largely responsible for the release of inflammatory mediators. When stimulated, these nerve fibers in the cutaneous nerves release active neuropeptides – substance P and calcitonin gene related peptide (CGRP) – rapidly into the microenvironment, triggering a series of inflammatory responses<ref name="1" /><ref name="2" /><ref name="3" /><ref name="4" /><ref name="5" /><ref name="6">Skaper SD, Facci L, Giusti P 2014 Mast cells, glia and neuroinflammation: partners in crime? Immunology 141: 314-27.</ref>. <br> | Fine unmyelinated afferent somatic C-fibers, which respond to low intensity mechanical and chemical stimulations, are largely responsible for the release of inflammatory mediators. When stimulated, these nerve fibers in the cutaneous nerves release active neuropeptides – substance P and calcitonin gene related peptide (CGRP) – rapidly into the microenvironment, triggering a series of inflammatory responses<ref name="1" /><ref name="2" /><ref name="3" /><ref name="4" /><ref name="5" /><ref name="6">Skaper SD, Facci L, Giusti P 2014 Mast cells, glia and neuroinflammation: partners in crime? Immunology 141: 314-27.</ref>. <br> | ||
< | Although neurogenic inflammation and immunologic inflammation can exist at the same time, the two are not clinically identical<ref name="1" />. There is a<span style="font-size: 13.28px;">n important distinction from immunogenic inflammation, which is the very first protective and reparative response generated by the immune system when a pathogen enters the body<ref name="2" />9,10.</span><span style="font-size: 13.28px;"> </span><span style="font-size: 13.28px;">.</span><span style="font-size: 13.28px;">Neurogenic inflammation involves a direct relationship between the nervous system and the inflammatory reaction. Although neurogenic inflammation and immunologic inflammation can exist at the same time, the two are not clinically identical2.</span> | ||
<br> | <br> | ||
Revision as of 10:50, 18 January 2017
Neurogenic inflammation (NI) is the physiological process by which mediators are released directly from the cutaneous nerves to initiate an inflammatory reaction. This results in production of local inflammatory responses including erythema, swelling, temperature increase, tenderness, and painCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title.
Fine unmyelinated afferent somatic C-fibers, which respond to low intensity mechanical and chemical stimulations, are largely responsible for the release of inflammatory mediators. When stimulated, these nerve fibers in the cutaneous nerves release active neuropeptides – substance P and calcitonin gene related peptide (CGRP) – rapidly into the microenvironment, triggering a series of inflammatory responsesCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title.
Although neurogenic inflammation and immunologic inflammation can exist at the same time, the two are not clinically identicalCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title. There is an important distinction from immunogenic inflammation, which is the very first protective and reparative response generated by the immune system when a pathogen enters the bodyCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title9,10. .Neurogenic inflammation involves a direct relationship between the nervous system and the inflammatory reaction. Although neurogenic inflammation and immunologic inflammation can exist at the same time, the two are not clinically identical2.
