Neurogenic inflammation in Musculoskeletal Condition: Difference between revisions
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In order to fully appreciate the involvement of NI in various clinical conditions, it is important to understand its mechanism of action. To date, two possible mechanisms of NI – backfiring<ref name="1" /> and neurogenic | In order to fully appreciate the involvement of NI in various clinical conditions, it is important to understand its mechanism of action. To date, two possible mechanisms of NI – backfiring<ref name="1" /> and neurogenic switching<ref name="8">Meggs WJ 1995 Neurogenic switching: a hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity. Environmental health perspectives 103: 54-6</ref><ref name="9">Meggs WJ 1993 Neurogenic inflammation and sensitivity to environmental chemicals. Environmental health perspectives 101: 234-8.</ref> – have been proposed. | ||
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Revision as of 10:55, 18 January 2017
Neurogenic inflammation (NI) is the physiological process by which mediators are released directly from the cutaneous nerves to initiate an inflammatory reaction. This results in production of local inflammatory responses including erythema, swelling, temperature increase, tenderness, and painCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title.
Fine unmyelinated afferent somatic C-fibers, which respond to low intensity mechanical and chemical stimulations, are largely responsible for the release of inflammatory mediators. When stimulated, these nerve fibers in the cutaneous nerves release active neuropeptides – substance P and calcitonin gene related peptide (CGRP) – rapidly into the microenvironment, triggering a series of inflammatory responsesCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title.
Although neurogenic inflammation and immunologic inflammation can exist at the same time, the two are not clinically identicalCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title. There is an important distinction from immunogenic inflammation, which is the very first protective and reparative response generated by the immune system when a pathogen enters the bodyCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title while neurogenic inflammation involves a direct relationship between the nervous system and the inflammatory reactionsCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title. Although neurogenic inflammation and immunologic inflammation can exist concurrently, two are not clinically identical.
Mechanism
In order to fully appreciate the involvement of NI in various clinical conditions, it is important to understand its mechanism of action. To date, two possible mechanisms of NI – backfiringCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title and neurogenic switchingCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive titleCite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title – have been proposed.
