Plantar Fibromatosis

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Search Timeline: Februari, 2013 - April, 2013

Definition/Description

Ledderhose diseaese, also known as plantar fibromatosis or Morbus Ledderhose, is a (mostly) small slow-growing thickening of the superficial fibromatoses wich is actually a soft tissue tumor of the plantar aponeurosis similar in appearance to the disease which occurs in the palm of the hand (disease of Dupuytren). Basically it can be described as a benign fibroblastic proliferative disorder in which fibrous nodules may develop in the plantar aponeurosis, more specifically on the medial plantar side of the foot arch and on the fore foot region. The symptoms are swelling, pain is not usual and also a contraction is not applicable in the first stage. [4],[6],[9],[10]

Clinical Relevant Anatomy

The plantar fascia, or aponeurosis is synonymous with the deep fascia of the sole of the foot. The plantar fascia is a strong connective tissue structure that consists of pearly white longitudinally organized fibers. It begins at the medial tuberosity of the calcaneus where it is thinner and extends into a thicker center portion. This thicker portion is flanked by thinner lateral and medial portions. The thicker central portion of the plantar fascia then extends, into five different bands surrounding the digital tendons, to the plantar plates of the metatarsophalangeal joints and the bases of the proximal phalanges. , [9],[13]

Figure 1: Plantar and medial views of the foot demonstrating the origin and insertion of the plantar fascia and the location of nerves in proximity to the heel.

Epidemiology/ etiology

Ledderhose’s disease, is named after a German surgeon, Dr. Georg Ledderhose. He described the condition first in 1894 as an uncommon hyperproliferative plantar aponeurosis ,[6]

Ledderhose’s disease is listed as a “rare disease” by the Office of Rare Diseas-es (ORD) of the National Institutes of Health (NIH), which means that it affects less than 200,000 people in the United State’s population.

Plantar Fibromatosis occurs less frequently than the palmar disease, with a prevalence of 0.23% and usually more frequently in middle aged male individuals (30 – 50 years). So men are affected twice as often as females and incidence increases with advancing age. Bilateral involvement is seen in 25 % of patiënts.[5],[10]

Due to the lack of information about the formation of this condition, the etiology is still controversial. But the plantar disease seems to have a multifactorial etiology, for example diabetis mellitus, genetic and traumatic causes (like a puncture wound or a micro-tear), family history and cancer incidence. [5], [10], [12]

Patients with the contracture of Dupuytren, diabetes mellitus, epilepsy, alcoholics with liver disease, stressfull work and keloids have more risk to develop the disease of Ledderhose and/or a the disease of Peyronie's. [5],[6], [9],[10]

Characteristics/Clinical Presentation

There will be a visible bulge, a soft- tissue mass composed of one or more subcutaneous nodules, on the medial (60%) or central (40%) plantar area of the foot same as a reduced capacity of bending the foot. The nodules may be multiple in 33% of cases and are typically slow growing. ,[4], [7], [8], [10]

Not all of the patients do have symptomatic complains. Complains such as pain can occur after standing or walking for a long time, or when those nodules happen to grow and stiffen the affected structures of the foot (due to a lack of space) such as neurovascular bundles, muscles or tendons. Nevertheless this disease typically do not cause symptoms such as contractures and patients do frequently have normal radiographs.[5], [10]

Plantar fibromatosis is thought to have three phases:

1) Proliferative phase: with nodular fibroblastic proliferation
2) Active phase: with collagen synthesis and deposition
3) Mature phase: with reduced fibroblastic activity and collagen maturation [9]

Figure 2: Subcutaneous nodules on the lateral aspect of the right foot and medial aspect of left foot and retraction.

Differential Diagnosis

Ledderhose’s disease is sometimes associated with other forms of fibromatosis, such as:
• Dupuytren’s disease
• Peyronie's disease
• knuckle pads

Some others main differential diagnoses are:
• plantar fasciitis
• chronic rupture of the plantar fascia [9]

Diagnostic Procedures

The identification of characteristics of plantar fibromatosis on imaging can give several important information for the clinical diagnosis.

Cross sectional imaging (ultrasonography, compute tomography, MRI) reveals the lesions location, extension and involvement of neighboring structures.

Evaluation is therefor most commonly performed with ultrasound and MRI. Sonographic imaging demonstrates a well-defined (64%) or poorly defined (36%) fusiform mass in the soft tissues adjacent to the plantar aponeurosis.

Plantar fibroma may be heterogeneous and hypoechoic (76%) or isoechoic (24%) relative to the plantar fascia . Posterior acoustic enhancement (20%), cystic components, and intratumoral hypervascularity (8%) have also been described. [5], [9],[10], [11]

Figure 3: A 54-year-old male who presents with left foot pain for one year. A longitudinal ultrasound color Doppler image demonstrates a soft tissue mass with heterogeneous echotexture and internal color Doppler flow (arrow). [5]

Figure 4: Sagittal T1-weighted fat saturation postcontrast sequence demonstrates a fusiform, enhancing lesion with linear extension along the plantar aponeurosis (arrow). [5]

Figure 5: Short axis T1-weighted sequence reveals lesion signal intensity similar to skeletal muscle. There is heterogeneity with several foci of low signal (curved arrows) within the lesion. [5]

Figure 6: T1- weighted postcontrast fat saturation sequence demonstrate marked heterogeneous enhancement (arrow).[5]

Medical Management

Even though a recovery with a non-invasive treatment is possible, certain severity of the lesion will demand a different approach. Therefor surgical treat-ment is indicated in cases of persistent pain or if large, infiltrative lesions cause significant disability and that are refractory to non-operative management or if conservative measures fail. The standard procedure and the most functional surgery nowadays includes a partial fasciectomy of the plantar aponeurosis in order to release the tension. After partial resection, there is a high recurrence rate with an increased risk of complications and more aggressive ingrowth into anatomical structures. Some authors recommend a complete fasciectomy as the primary procedure of choice. Postoperative radiotherapy can be used to diminish the chance of recurrence. ,[6],[7],[8] [10],[11], [16]

Also medical treatment can consist of non steroidal antirheumatic drugs or local cortisone-injections. [3]

During the first phase (1-3th day) the foot of the patient will be placed in a position to function. Mainly this phase will consist of: prevent post-operative oedema by raising the foot, ask the patient to mobilize the toes. If none postoperative immobilization is provided: an active mobilization will be required from the first days.

Prefabricated or custom foot orthoses show? can be used to provide short-term (3 months) reduction in pain and improvement in function. There appear to be no differences in the amount of pain reduction or improved function created by custom foot orthoses in comparison to prefabricated orthoses. There is currently no evidence to suport the use of prefabricated or custom foot orthoses for long-term (1 year) pain management or function improvement. [3], ,[6],[7],[8]

Movie: http://www.youtube.]com/watch?v=we8NXXYfCgk

Physical Therapy Management

Treatment of plantar fibromatosis is conservative in the majority of patients and consists of stretching, physiotherapy, footwear modifications, pads, or orthotics aimed at relieving symptoms. ,[8],[10]

Shockwave therapy seems also to have an effective effect on plantar fibromatosis, by reducing the pain and soften the nodules. [6],[15]

The wound healing phase; 8-15st day, will consist of: mobilization of the free articulations, circulatory and scar tissue massage (although there is only weak evidence for massage in scar management), lymphatic drainage, pneumatic/air pressure therapy, recovery of the joint capsulas, cartilage and muscles of the toes (slow and painless passive mobilization, active mobilization, work on the posture extension), ionization, lasers, US if there is a bad wound healing.

Calf muscle and/or plantar fascia-specific stretching can be applied to provide short-term (2-4 months) pain relief and improvement in calf muscle flexibility. The dosage for this stretching can be either 3 times a day or 2 times a day utilizing either a sustained (3 minutes) or intermittent (20 seconds) stretching time, as neither dosage produced a better effect. [3], [14]

The phase after the wound healing, will consist of: a circulation and scar massage, bath of hot water or paraffine with active movements, total recovery of the articular amplitudes (by using analytic and global active-passive exercises and postural extension if needed with a dynamic brace), recovery of the muscle force (manually and later on with growing mechano-therapy appliances).

There is minimal evidence to support the use of manual therapy to provide short-term (1 to 3 months) pain relief and improved function. Suggested manual therapy procedures include anterior and posterior glides of tarsometatarsal, metatarsalphalangeal and interphalangeal joints.[3]

References

1. Yusuf Ziya Tatli - Sameer Kapasi, The real risks of steroid injection for plantar fasciitis, with a review of conservative therapies, Human Press 2:3-9 (2008). Level of evidence 2A

2. Fausto de Souza, D. et al. (2010). Ledderhose Disease: An Unusual Presentation. The journal of Clinical and Aesthetic Dermatology, 3. Level of evidence: 3B

3. Thomas G.MCP., Robroy L.M., Mark W.C., Dane K.W., James J.R., Joseph J.G., (2008) , Heel Pain – Plantar Fasciitis : Clinical Practice Guidelines Linked to the International Classification of Function, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association, J Orthop Sports Phys Therp. Level of evidence : 2

4. Haedicke, G.J., Sturim, H.S. (1989). Plantar fibromatosis: an isolated disease. Plast Reconstr Surg. Level of evidence: 4

5. Walker, E.A., Petscavage, J.M., Brian, P.L., Logie, C.I., Montini, K.M., Murphey, M.D. (2012). Imaging features of superficial and deep fibromatoses in the adult population. Sarcoma. Level of evidence: 2A

6. Knobloch, K. & Vogt, K.M. (2012). High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose’s disease). BMC Res Notes. Level of evidence: 2A

7. Van der Veer, W.M., Hamburg, S.M., de Gast, A., and Niessen, F.B. (2008). Recurrence of plantar fibromatosis after plantar fasciectomy: single-center long-term results. Plast Reconstr Surg. Level of evidence: 2A

8. Beckmann, J., Kalteis, T., Baer, W., Grifka J., and Lerch, K. (2004). Plantar fibromatosis: therapy by total plantarfasciectomy. Zentralbl Chir. Level of evidence: 4

9. Griffith, J.F., Wong, T.Y., Wong, S.M., and Metrweli, C. (2002). Sonography of plantar fibromatosis. AJR Am J Roentgenol. Level of evidence: 2A

10. Murphey, M.D., Ruble, C.M., Tyszko, S.M., Zbojniewicz, A.M., Potter, B.K., and Miettinen, M. (2009). Musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. Level of evidence: 2C

11. Robbin M.R., Murphey M.D., Temple H.T., Kransdorf M.J., Choi J.J. (2001). Imaging of Musculoskeletal Fibromatosis. RadioGraphics, the journal of continuing medical education in radiology. Level of evidence: 1B

12. Pack, G.T., & Ariel, I.M. (1964). Treatment of cancer and allied diseases Volume VIII: Tumors of the soft somatic tissues and bone / by thirty-nine authors. P.B. Hoeber. Level of evidence: 4

13. Eugene G. McNally, Shilpa Shetty. (2010). Plantar Fascia: Imaging Diagnosis and Guided Treatment. Department of Radiology, Nuffield Orthopaedic Centre, Oxford, Oxfordshire, United Kingdom. Level of evidence 1B

14. Shin TM, Bordeaux JS.(2012). The role of massage in scar management: a literature revision. Department of Dermatology, Cleveland, Ohio, USA.
Level of evidence 1A

15. Knobloch K., Vogt PM., (2012), High-energy focused extracorporal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose’s disease). Hannover Medical School, Germany. Level of evidence 2B

16. Seegenschmiedt MH, Attassi M,. (2003), Radiation therapy for Morbus Ledderhose – Indication and clinical results. Essen, Germany. Level of evidence 2B