The Influence of NSAIDs on Physiologic Processes and Exercise: Difference between revisions
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Non-Sterodial Ani-Inflammatory Drugs (NSAIDs), including acetaminophen (Asprin) and Ibuprophen, simply put, reduce inflammation and pain. NSAIDs are widely and commonly used, which is why researchers are countinuously studying the risks and benefits of their effects on the human body. | Non-Sterodial Ani-Inflammatory Drugs (NSAIDs), including acetaminophen (Asprin) and Ibuprophen, simply put, reduce inflammation and pain. NSAIDs are widely and commonly used, which is why researchers are countinuously studying the risks and benefits of their effects on the human body. | ||
NSAIDs work by inhibiting the activity of an enzyme called cycoloxygenase (COX), which is crucial in the formation of prostaglandins. Prostaglandins play a role in the generation of pain and in the inflammatory response; however, they also have roles in many other bodily functions. When NSAID's inhibit prostaglandin synthesis they can reduce pain and inflammation, but they can also hamper gastrointestinal functions and post-exercise protein synthesis, as well as cause a number of other positive and negative side effects. These effects on physiological processes and exercise are further discussed for the following body systems: muscular, cardiovascular, metabolic, pulmonary, neuromotor and gastrointestinal. | NSAIDs work by inhibiting the activity of an enzyme called cycoloxygenase (COX), which is crucial in the formation of prostaglandins. Prostaglandins play a role in the generation of pain and in the inflammatory response; however, they also have roles in many other bodily functions. When NSAID's inhibit prostaglandin synthesis they can reduce pain and inflammation, but they can also hamper gastrointestinal functions and post-exercise protein synthesis, as well as cause a number of other positive and negative side effects<ref>Warden, S. (2010). Prophylactic Use of NSAIDs by Athletes: A Risk/Benefit Assessment. The Physician and Sportsmedicine, 38(1), 132-138.</ref>. These effects on physiological processes and exercise are further discussed for the following body systems: muscular, cardiovascular, metabolic, pulmonary, neuromotor and gastrointestinal. | ||
<u>'''Muscular'''</u> | <u>'''Muscular'''</u> | ||
Based on the literature, the effects of NSAIDs on the muscular system differs for young individuals vs. old individuals, acute vs. chronic use, and for timing of use (pre vs. post exercise)[[]] <ref>Trappe, T. A., Standley, R. A., Jemiolo, B., Carroll, C. C., &amp;amp; Trappe, S. W. (2013) Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology (3)304. 198 -205. DOI: 10.1152/ajpregu.00245.2012</ref><ref>Trappe, T. A., Carroll, C. C., Dickinson, J. M., LeMoine, J. K., Haus, J. M.,... &amp;amp; Hollon, C. J. (2011)Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology (300)3, 655-662. DOI:10.1152/ajpregu.00611.2010</ref><ref>Baldwin, A., Stevenson, S., &amp;amp; Dudley, G. (2001). Nonsteroidal Anti-Inflammatory Therapy After Eccentric Exercise in Healthy Older Individuals. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(8), M510-M513. doi:10.1093/gerona/56.8.M510</ref>[[]]<ref>Krentz, J., Quest, B., Farthing, J., Quest, D., &amp;amp; Chilibeck, P. (2008). The effects of ibuprofen on muscle hypertrophy, strength, and soreness during resistance training. Applied Physiology, Nutrition, and Metabolism, 33(3), 470-475. doi:10.1139/H08-019</ref><span style="line-height: 1.5em;"><ref>Warden, S. (2010). Prophylactic Use of NSAIDs by Athletes: A Risk/Benefit Assessment. The Physician and Sportsmedicine, 38(1), 132-138.</ref></span>'''<span style="line-height: 1.5em;">*NOTE: include additional supporti</span><span style="line-height: 1.5em;">ng refferences here</span>'''<span style="line-height: 1.5em;">. </span> | Based on the literature, the effects of NSAIDs on the muscular system differs for young individuals vs. old individuals, acute vs. chronic use, and for timing of use (pre vs. post exercise)[[]] <ref>Trappe, T. A., Standley, R. A., Jemiolo, B., Carroll, C. C., &amp;amp;amp; Trappe, S. W. (2013) Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology (3)304. 198 -205. DOI: 10.1152/ajpregu.00245.2012</ref><ref>Trappe, T. A., Carroll, C. C., Dickinson, J. M., LeMoine, J. K., Haus, J. M.,... &amp;amp;amp; Hollon, C. J. (2011)Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology (300)3, 655-662. DOI:10.1152/ajpregu.00611.2010</ref><ref>Baldwin, A., Stevenson, S., &amp;amp;amp; Dudley, G. (2001). Nonsteroidal Anti-Inflammatory Therapy After Eccentric Exercise in Healthy Older Individuals. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(8), M510-M513. doi:10.1093/gerona/56.8.M510</ref>[[]]<ref>Krentz, J., Quest, B., Farthing, J., Quest, D., &amp;amp;amp; Chilibeck, P. (2008). The effects of ibuprofen on muscle hypertrophy, strength, and soreness during resistance training. Applied Physiology, Nutrition, and Metabolism, 33(3), 470-475. doi:10.1139/H08-019</ref><span style="line-height: 1.5em;"><ref>Warden, S. (2010). Prophylactic Use of NSAIDs by Athletes: A Risk/Benefit Assessment. The Physician and Sportsmedicine, 38(1), 132-138.</ref></span>'''<span style="line-height: 1.5em;">*NOTE: include additional supporti</span><span style="line-height: 1.5em;">ng refferences here</span>'''<span style="line-height: 1.5em;">. </span> | ||
''Young vs. Old'' | ''Young vs. Old'' | ||
Revision as of 02:36, 5 November 2015
Introduction
Non-Sterodial Ani-Inflammatory Drugs (NSAIDs), including acetaminophen (Asprin) and Ibuprophen, simply put, reduce inflammation and pain. NSAIDs are widely and commonly used, which is why researchers are countinuously studying the risks and benefits of their effects on the human body.
NSAIDs work by inhibiting the activity of an enzyme called cycoloxygenase (COX), which is crucial in the formation of prostaglandins. Prostaglandins play a role in the generation of pain and in the inflammatory response; however, they also have roles in many other bodily functions. When NSAID's inhibit prostaglandin synthesis they can reduce pain and inflammation, but they can also hamper gastrointestinal functions and post-exercise protein synthesis, as well as cause a number of other positive and negative side effects[1]. These effects on physiological processes and exercise are further discussed for the following body systems: muscular, cardiovascular, metabolic, pulmonary, neuromotor and gastrointestinal.
Muscular
Based on the literature, the effects of NSAIDs on the muscular system differs for young individuals vs. old individuals, acute vs. chronic use, and for timing of use (pre vs. post exercise) [2][3][4][5][6]*NOTE: include additional supporting refferences here.
Young vs. Old
Acute vs. Chronic Use
Timing of Use (Pre vs. Post Exercise)
Skeletal
Cardiovascular
Metabolic
Pulmonary
Neuromotor
Gastrointestinal
Conclusion
- ↑ Warden, S. (2010). Prophylactic Use of NSAIDs by Athletes: A Risk/Benefit Assessment. The Physician and Sportsmedicine, 38(1), 132-138.
- ↑ Trappe, T. A., Standley, R. A., Jemiolo, B., Carroll, C. C., &amp;amp; Trappe, S. W. (2013) Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology (3)304. 198 -205. DOI: 10.1152/ajpregu.00245.2012
- ↑ Trappe, T. A., Carroll, C. C., Dickinson, J. M., LeMoine, J. K., Haus, J. M.,... &amp;amp; Hollon, C. J. (2011)Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology (300)3, 655-662. DOI:10.1152/ajpregu.00611.2010
- ↑ Baldwin, A., Stevenson, S., &amp;amp; Dudley, G. (2001). Nonsteroidal Anti-Inflammatory Therapy After Eccentric Exercise in Healthy Older Individuals. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(8), M510-M513. doi:10.1093/gerona/56.8.M510
- ↑ Krentz, J., Quest, B., Farthing, J., Quest, D., &amp;amp; Chilibeck, P. (2008). The effects of ibuprofen on muscle hypertrophy, strength, and soreness during resistance training. Applied Physiology, Nutrition, and Metabolism, 33(3), 470-475. doi:10.1139/H08-019
- ↑ Warden, S. (2010). Prophylactic Use of NSAIDs by Athletes: A Risk/Benefit Assessment. The Physician and Sportsmedicine, 38(1), 132-138.
