Motoric Cognitive Risk Syndrome
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton
Introduction[edit | edit source]
Motoric cognitive risk syndrome (MCR) is a syndrome that develops prior to dementia. The syndrome consists of a slower gait and cognitive complaints. New research is showing that gait dysfunction can be a harbinger of dementia.[1]
MCR amongst older persons is estimated to be 10% in the 60 + age group, giving this popolation a higher risk of future disability.
Exercise has been to shown to have a role in preventing cognitive decline. Home-based exercises with telephonic coaching are both safe as well as feasible in patients with Motoric Cognitive Risk syndrome[2]
Pathology[edit | edit source]
Both neurological and non-neurological clinical abnormalities are evident. Gait irregularities and fast functional decline (eg postural and balance dysfunction, memory loss, cognitive decline) stemming from altered afferent sensory and efferent motor responses, in tandem with confusing visual, vestibular, and proprioceptive inputs. The pathology of MCR is attributed to frontal lacunar infarcts, for example white matter hyperintensity (WMH), pre-motor and pre-frontal gray matter atrophy in the pre-motor and pre-frontal cortex, inflammatory responses, and genetic factors. Cerebrovascular lesions and cardiovascular disorders amplify the disease pathology. [3]
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References[edit | edit source]
- ↑ Meiner Z, Ayers E, Verghese J. Motoric cognitive risk syndrome: a risk factor for cognitive impairment and dementia in different populations. Annals of geriatric medicine and research. 2020 Mar;24(1):3.Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370775/(accessed 12.4.2023)
- ↑ Ambrose AF, Gulley E, Verghese T, Verghese J. Home-based exercise program for older adults with Motoric Cognitive Risk syndrome: feasibility study. Neurodegenerative disease management. 2021 Jun;11(03):221-8.Available:https://www.futuremedicine.com/doi/full/10.2217/nmt-2020-0064 (accessed 12.4.2023)
- ↑ Xiang K, Liu Y, Sun L. Motoric cognitive risk syndrome: symptoms, pathology, diagnosis, and recovery. Frontiers in Aging Neuroscience. 2022 Feb 2;13:728799.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847709/ (accessed 12.4.2023)
