Granulomatosis with Polyangiitis
Original Editors - Dalie Camic & Daryl Williams from Bellarmine University's Pathophysiology of Complex Patient Problems project.
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Definition/Description[edit | edit source]
Wegener's granulomatosis is a rare disorder characterized by inflammation in the blood vessels, which in turn decreases blood flow to organs and systems. Most affected areas include the kidneys, lungs, and upper respiratory tracts.
Prevalence[edit | edit source]
Wegener's granulomatosis is most common in middle aged adults, but has been seen in children as young as 3 months of age.
Characteristics/Clinical Presentation[edit | edit source]
The signs and symptoms of Wegener's Granulomatosis are not only common signs and symptoms of other diseases or illnesses but are often vague in the beginning presentations of this disease. The first signs and symptoms include upper respiratory tract symptoms, joint pains, weakness, and tiredness.
Respiratory System
-Common involvement occurs in the upper respiratory tract in nearly all patients.
-Symptoms include: sinus pain, discolored or bloody fluid from nose, and nasal ulcers.
Common signs include: rhinorrhea ("runny nose"), common cold symptoms that do NOT respond to usual treatment and become increasingly worse. Although this these are the most prevelant signs Wegener's Granulomatosis is rarely the cause.
-Lungs: Commonly affected in patients with Wegener's Granulomatosis there are rarely signs and symptoms that present. Possible S&S can include cough, hemoptysis, shortness of breath, and chest discomfort.
-Musculoskeletal system: Although it does not lead to permanene joint damage or deformities pain in the muscle and joints along with joint swelling affects two-thirds of individuals with this disease.
-Other signs and symptoms can include develop skin lesions resmembling red or purple raised lesions. The eyes can be affected causing conjunctivitis, scleritis, episcleritis causing double vision, redness, burrning, and pain. Symptoms involving the eyes require immediate medical attention.
Associated Co-morbidities[edit | edit source]
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Etiology/Causes[edit | edit source]
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References[edit | edit source]
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