Graves' Disease

 

Welcome to PT 635 Pathophysiology of Complex Patient Problems This is a wiki created by and for the students in the School of Physical Therapy at Bellarmine University in Louisville KY. Please do not edit unless you are involved in this project, but please come back in the near future to check out new information!!

Original Editors - Erin Shinkle from Bellarmine University's Pathophysiology of Complex Patient Problems project.

Lead Editors - Your name will be added here if you are a lead editor on this page.  Read more.

Definition/Description

Graves’ is classified as an autoimmune disease that affects the thyroid gland. It causes goiters, hyperthyroidism, ophthalmopathy, and occasionally dermopathy.(ginsberg) Graves'  disease is known for increasing the thyroid stimulating hormone raising the T4 levels and is known as the number one cause of hyperthyroidism.(DD) Hyperthyroidism/Graves' disease can manifest itself in multiple systems(link to hyperthyroidism page).

Prevalence

Graves’ disease is more prevalent in the Caucasian race affecting more women than men at a ratio of 4:1 and ages range from 30-60years (Hemmiki and DD). Graves’ disease accounts for 85% of all cases of hyperthyroidism. (Pathology)

Characteristics/Clinical Presentation

Goiter, Exophthalmos, tremors, tachycardia with palpitations, heat intolerances, weight loss, increased deep tendon reflexes, weakness and muscle atrophy, increased cardiac output, myasthenia gravis, thin hair, warm moist skin, sensitivity to light, dysphasia, diarrhea, amenorrhea, polyuria, and many other presentations some of which may not be as common and more subtle. (pathology)

Associated Co-morbidities

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Medications

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Diagnostic Tests/Lab Tests/Lab Values

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Etiology/Causes

Has both a genetic, lack of suppressor t-cells causing increase in TSH receptor antibodies, and environmental causes which includes, but not limited to the following: stress, smoking, post pardum, and infections (Hemminki and ginsburg)

Systemic Involvement

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Medical Management (current best evidence)

The current best management of Graves' disease varies upon several factors of the individual recieving it. The options include partial and full removal of thyroid gland, antithyroid drug therapy, radioiodine therapy (franklyn).

Physical Therapy Management (current best evidence)

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Alternative/Holistic Management (current best evidence)

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Differential Diagnosis

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Case Reports/ Case Studies

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Resources

National Graves' Disease Foundation

      http://www.ngdf.org/

American Thyroid Association (ATA)

       http://thyroid.org/

American Association of Clinical Endocrinologists (AACE)

       http://www.aace.com/

The Endocrine Society

       http://www.endo-society.org/

The Hormone Foundation

        http://www.hormone.org/

American Autoimmune Related Diseases Associations (AARDA)

         http://www.aarda.org/

Recent Related Research (from Pubmed)

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References

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