Interstitial Cystitis

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Definition/Description

Interstitial cystitis (IC) is a disorder affecting the bladder characterized by uroepithelial inflammation and/or hypersenstivity of the afferent nerves of the bladder.(Oyama, IA)

Prevalence

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Associated Co-morbidities

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Medications

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Diagnostic Tests/Lab Tests/Lab Values

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Causes

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Systemic Involvement

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Medical Management (current best evidence)

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Physical Therapy Management (current best evidence)

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Alternative/Holistic Management (current best evidence)

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Differential Diagnosis

NIDDK* Diagonostic Critera for Interstitial Cystitis (MacDiarmid SA)

Automatic Inclusion:

• Hunner's ulcer

Positive factors (2 must be present for inclusion):

• Pain on bladder filling relieved by emptying
• Pain (suprapublic, pelvic, urethral, vaginal, or perineal)
• Glomerulations on cystoscopy
• Decreased compliance on cystometrogram

Exclsuions:

• Nocturia < 2 times per night
• Symptoms duration < 12 months
• Bladder Capacity > 400 mL
• Involuntary bladder contractions
• Other causes of sxs:

Bladder Cancer, Cystitis (radiation, tuberculous, bacterial, vaginitis, active herpes, bladder or lower calculi, involuntary bladder contractions.

• NIDDK- National Institute of Diabetes and Digestive and Kidney Diseases

Case Reports

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Resources

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Recent Related Research (from Pubmed)

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References

Mac Diarmid SA, Sand PK. Diagnosis of Interstitial Cystitis/Painful Bladder Syndrome in Patients with Overactive Bladder Symptoms. Rev. Urol. 2007; 9 (1): 9-16.

Oyama IA, Reijba A, Lukban JC, Fletcher E, et al. Modified Thiele Massage as Therapeutic Intervention for female Patients with Interstitial Cystitis and High-Tone Pelvic Floor Dysfunction. Urology.; 64 (5): 862-865.